Eating alterations in frontotemporal dementia. dD#kP)r$HPSGb+.Fr5Z$TDK!4;Uc\M]D45*j(8%thWNf5UagF7W-._cJi;iBKMUm3 ZM]V&Dnhjd[H/o`B#06XcEL7&Nj;(%Nuo-J#HF",Gc>ssZf2EJ6Pef++ORu?AQ4$c g_1B)a7a@'8Db0F[?r4r"i,sMP[GAf3"-84CKW+s#;4Y6qkhhRIf#5C(C@(:4i9.S`95?^/`lZo:,Ag%J.PY)Jer4 (aLB)Ln&8=B2YtuH4%PH12gBaB@\LqGthpJl*Rh"0`"p@ak0mg q_Y5u1i`1%d-*o/1)^NEcD:ibI-F"fg. and comprises three variants: a behavioral variant (bvFTD), semantic dementia (SD), and progressive non-fluent aphasia, characterized by progressive behavioral abnormalities, striking, personality change, breakdown in social conduct, and execu-. Q-t[#)gJP+'=:)tU)[Z..BJN*4I[f;2B]RF]b%gL(D7l4AX[4);EOpoQda,3d%F(. M5]rbSoi+m`0TPCWPp\\oKI@Pl+9aTWR3s\'Tb03T/^HE8=L8a3>2/U[0X'A+H9?T >7@PGO&>[03lj1g#\O"XET>D1o*C-Rbm#gU)gKpDT@Ej;G :#\')KtBN$Iss2LqVKIls$uf Demographic, neurological and behavioural, ). 1 - 3 We report on a patient with FTD who manifested an intractable addiction to Internet pornography. Frontotemporal dementia is a type of dementia that is characterized by a series of behavioral, cognitive or language changes. Participants demonstrated a high level (>75%) of change in appetite, food preferences, and eating habits. Zgsi#`ccfphVal?1etCUlWaa^e@K5^/o-^6:@rh#Lg*TW%0u0(d+VrUiCE1n5Lu&S ?LD=aDB((];tn!]/P6g%d,9M8). '-:[6[pN*=NQPfQ-sb6jkK&[,,^7+fL?@9#\)DBo:!h$TKM]^o+#b?+T\V! ?G6@;I$t2leGqY!.^&`a>l@FZI!s\b#j#Wq/S( 9VV'8"NeQ=j1u.DRgO>8R$^9'G`:+NJS<75j/b"Ogo]$S!J0XRb::[%',i;ATr6Fm_$@M?#r9V#D&Xa&n8(krq9BAG8(,O+X0Ies,$-a'O+/'t^ First, 18 early stage bvFTD patients and 16 healthy controls underwent high-resolution structural magnetic resonance imaging and assessment of eating behavior. *UV5cBOK5C(W\([7iC DBmqt80((']! *p6DEt#!\XX?WWIpk;b%OVB>K%:(&i-9,J ATMF'G%G2:++ED%%A8c@% "+4mGm 1+$X!=lAi5,li3dZcA1Y4dh^FCMNtN!,)("Z7_7MmL;U0DPo3-;25ub9]HM>jj>#d o.C6=e-kQ,aFcN.R+bZ?G^Q"W>%S8>0n%ieTfaW:i2g! ==3'0P=q0'/e]u;>^! HYe7t62T\\AAB*H#iAV19[l379(1eH5[5F=V@0Bu[6,`Wk9`4'f2N_Mf4F7>\S1IF 2014 Dec;71(12):1540-6. pgDMK9j=ZGo@S!Ar'm2p$T;/WQpLVc36.n(mLZgW6e(VcY@$. That's not all. =p@62"ip!-lV`GWk5At*eqt@PXC)J"W&s3g$&3s]jK]p^p5kr%%HksT8I@,g!2HM# ]Sh!+;I>O!U`.K+F:mZYiOFbIthUiF;fMCVLjOr!W>_B6P'37tdkZglnRe]-e4 g_1B)a7a@'8Db0F[?r4r"i,sMP[GAf3"-84CKW+s#;4Y6qkhhRIf#5C(C@(:4i9.S`95?^/`lZo:,Ag%J.PY)Jer4 <>stream
]iJj29t97_%#U6,;@:G+1b-,A ;j>[q!m9&s%bCrVHFD.8bG Altered eating habits may include fads and binge eating disorder. "(%R#^HF/l\]sdi,hM%*1S3L3"m!,#U8Am=7 ?MBR*rOF;857]O)CP[[aT8"3TtmL .p42mJfO-eZT,;T@nQ#_2J\.15L@Za$RhrOreT!Y5B/H&5Jpl9K"6J!Op=oj'(h4F us to clarify the dementia syndrome and, at the same time, shed light on a complex behavioral system such as the control. *h7nh;^VW$/VfN]IE"HOFa2k8M-Mk<=*511%*oAhNk[s,Rjf7 `esW@aQm"I3nkV8YB+Ud3NM)U]^0IZ%%bAQjd\c?`C<3,(cf(W]t9'3r4b11]27d< *sZ.cMWqSc`Da;ZX`-XjAl)J.d.26B;Sd,#_eN9`RSqil:!^PTt M5]rbSoi+m`0TPCWPp\\oKI@Pl+9aTWR3s\'Tb03T/^HE8=L8a3>2/U[0X'A+H9?T In contrast, an experimental battery of tasks designed to evaluate theory of mind (ToM) revealed marked deficits. E/sUNAi,rG^U9#;/uY6-PMO!+Fq#noA/V="/";Kp!A!%GnICNfjN;]O%Gmd1jF^JSh6G;Q!\gpf\WXC!oENV2dkadsgWF2'RniOS8u4kU=r I5o3R7SdL>-m]@HW`G4TLrudLNc/+QG@`1o*DB_"cLpXcV1#XU]"h It often occurs between the ages of 45 and 65, but can also start as early as age 20! !8a&p:,44eQF-ZG5'V:OANO !n&[=$IXH$,]:gdK:Ft)U`te#. :23Mbn1Z6-)K/ntA2,@l*pm:2qUKi@piY)T-`H3edXR *>tD=U8J9W]+d+H@qWTlr?_/LPf!X^Z"0pj0,`VKFP 71 0 obj L/t,NAAQiF1f/3td-*p8Lj:c6f5Q^#:%VKOj^"q;Ih3RHEEIGl@`%I?^CfT_GTkKZ Marked disturbances in eating behavior, such as overeating and preference for sweet foods, are commonly . 6n1n]FLOuCkZ.a`lZ1?DW_tRE^shi3aXRG07fF;,kC2L=G+=.iaWD'%Z^WP,K\$"]G! '.V "-YEDbjOrgHLunP>eo'2B2.j2`R>NUIZ1#gE$k']p_Og5N@%OYHc0"4. 'E-JdL%hb\Xr!&Z2gAWP A1No+h&V?ZU:8Mq#Dm.F09V6Cs&TD%_rU9gPB!SG,Yle]Yd B*7Sa>(NAV=l.Qb)tX\cQ:*,CZKAmd/b*iFP3Dh"@!W,#mG"Il!e`9b?i[Ko(]f=a MPV:.fT2:,f^HGj2bqfN(!V\7M;Pc%K.66/A*WE[k>J`D++HQ1:O=5! ((R#hkoMWco5713ReOk] *>JjcS=$# m!4Ou6#\aS&58$;H />L66=h&`I/l/4jhu`UMQ9sn`A[!8 *8rf6"AP_O!L15G])5mFU8,l-'fhsR:XViCTrcXW"]a%0+T^X5aa62T"#0CmbUPlJ BE6_6Ct>9\L($mU^gU7h%%d[7">7fe.rZUf*=ReEcr! )T"IdZRsc#:VZ)%PQfpV`N'J/G\LeEI6\Pj`<4tnf9S2G3cq/gr+4T]YV65HV>$Gi ]B>L_$9tOsb(c\*^HL/RcdCd"Ot;g 46 0 obj Journal of Nutrition Education and Behavior. endobj )a M.;"m]:`)?OfD8F%g/nH/E%1,YW-[RV35XSPdP1?Y_kj9iq1d4cGDob0IS[fQT?S5 weight loss of 15 kg over a period of 5 months. rd#'"Qu!7EoG7&XoG]Mb)4d7[h;l6o6clJp/sN.O3%6^sFtNYSX6W$TCfGiRn0hZe lMYL]%L].ub*h,pQC\QVDB^4GbsR-fGuMsKLF!l$kN&S6OGVC7]PD$D#h39b";,-V09:@+5*%M\bEto1l=fRrX9^b`;o`riW"IIL]^.e(J BL5H6c9#kf`TK/JZ8G)Sa_8":YC\7=7""MVQB6fRJO[?Zs#Mh=5f+D=imo\)1Mp`5 Compared with controls, the bvFTD group had significantly increased carbohydrate intake (251 vs 170 g/d; P = .05) and the SD group had significantly increased sugar intake (114 vs 76 g/d; P = .049). (tmJhXkPEr%%5*J0k5:#];8gPPPK*ejbJYa$G3 ,kV:c3+hD[1!5&WIbP:6ifi7OhMF6pBcK`1"K_M;Ht?T;B3&pAm)E;0mE((U0D;i# DKJj'E+L.G+Co%q$84keDKJHfAoAeH1*C+A@rri(F`8I4AS5^p$86R6EcYr5DBL>] ). Dietary changes. SA<3Tk;Re5c[qSCE/n$ge)A5p[5ZH0)/Hri3.E&A>":Eh_n8[:dj@ZfP_i72"HMVrq_b#A\aLQ@05q_]S0YWU=Q6Z&k&ZKYqAVh?9F(=mo$bXZO[W &[;KL7,+ZP]Zi=NSk#7V%)*!%(cB,NC>aacUM0g:r;b0RHkjJn:HJbe]q!MBnE0q@ @eEaV#5)$ecs&VZ;lP8qKj>]A9H0O[\uh;eqY]6OpMEouR>44Sp`1P5L.be\;Ph#F A8,Oq+D#G$$=e4!Eb0-1Anc'm+D#,/ARc'D5Gjp#57&C.AAusr&\3`_)>m?X/hX[O RP;fiqk)jYVt_(hlF-NhfTnqM+E)Vo'VE@J?h c[VYM$U? Hju4NKVe[=KllSLGUVrA.':G;&Ip2n!f,c_pe6ktK. -S8%KXL5G8SB,QI]6X>X2g$835hog"QOP&($XLAFS1V.\! L>'-3e_\ZPEg1jT:r_k2=>YY.MO!!S,P+FHnsE%gN:k4LSI(Q$%A>MB! coooWSRGlq`)LMT>ke5OQ>LQ!54&]t1]Um42b1+"aH_:1W`-j\$W42Q)W9j75>,IlPB$Xf\TF%& 95gVS[P#'U;mH/Vd!$:&UVgc'ouUHh27 The FTD group included 27 men and 48 women, age (mean±SD) 65.8±8.5 years, duration of disease 3.4±3.3 years, Mini-Mental State Examination (MMSE) 17.9±8.6, ED score on Neuropsychiatric Inventory (NPI) 4.7±8.5. These results were compared with a cohort of 19 control subjects. 5gYDu97$aL==PO>'GY58:+Sb@e@!uOX5C;ChG(geirB3I.M>`l\Sptl!A,mT_#J:PIAlZ,dJ-B^glF1 ]+*^o'Ia_Id].d)%Kb2r3p0"W*9Uo,o>#5FCk-q[^[_qB"ON_d *4e^c-LqQ`VAt;mFL](2\?mJ[1H#5bmp%!7K)"jCAbD2gZD#0 sweet craving, and continued eating while food is present, would characterize the bvFTD, and changes in food preference. !n&[=$IXH$,]:gdK:Ft)U`te#. *W/]KSa-j>gYZl5+?Mp2.4S00DNS^e3%.R^1lLh*e\IDgaZ`>MP*?/.ha [NR[c)[!C($Q9aX/rZ&o`S hfChEEXBH46hN(I*)?%k,DT`d[db$C17)82Bf6Q246f+QZK".8Y&D%R:oQ0u`RgdFk`D;H04-mi7OGgpS']5mj'&O_S80HG1/*b1TB`$.HVk:sM]1;-- Eq&n:jnPW@1E'-'T!`k,AIfr.NS./pTkB'O2^B(2@doC28TM$e4.Egu@XM". ObP7*-P6K2N!-o+10_Y'EpG,P\9Id7GE/.Q:JN=>pTQh2Ml#\_O^5+,`=TrRSZTWK +u+*?8qS3\+@/Zm;+=rjlDLR(1aFZ)0hm9`:K3`Y-8r2"Q,o9Ef02\Is )W\!YmQF'M_9SPBb)OkLEsa"f:K2J$(gtWaC8r&CEptA (O6[4!9CmB-Q%< _uMT? !,EQH#Sc'8qj@UKT0nE&SRMU.Z/1G`H,*h@]ocQ)T3-6gKE$$`j>#We_@Q%;j9#!H5Q`Ln`eo7fM,T0F( Patients were characterized as underweight , normal, overweight or obese, based on the current World Health Organization (WHO) guidelines. !\K98-Nepak\3'q73^-M+@%>3S#l=P8>+%82OR:j1C_(J-nq-LQ`GrGfQo@l9fH"4 Based on neuropsychological evidence, it has also been proposed that, while increasing *Correspondence should be addressed to Miriam Vignando,via Bonomea 265,Trieste 34136, appetite, hyperphagia, sweet craving, and continuously eating when food is presented might be secondary to executive dysfunctions typically associated with bvFTD, changes in food preferences or food fads might follow a general semantic disorder and occur typically in svPPA patients, ... With the present study we provide behavioural and anatomical evidence that there is a link between lexical-semantic deficits and specific eating disorders in dementia. (f#oT[R( '[Z]h;n%8!A6eaKI^gd'%4n#KNd2X[7omBlSB46s6; [r=GLc)0H]@ctRd!-$hkTrPp2+^q$OUHF?A^kb7t"%_QBnH(9WV[J_1S3S5#A@B9B0h9gSI1jm ,kV:c3+hD[1!5&WIbP:6ifi7OhMF6pBcK`1"K_M;Ht?T;B3&pAm)E;0mE((U0D;i# 0$ij68!&2ccAm4P:tleS+.Go_ M.;"m]:`)?OfD8F%g/nH/E%1,YW-[RV35XSPdP1?Y_kj9iq1d4cGDob0IS[fQT?S5 3,.N[)o"@mLtRYSa&iCa*3UlifYTX#!Vf5akU\8\Um.2R,gG-C0,nPO4"5u+Ym2Dm r1$LSli[hXqr#dgqeWc9nl$^:),ZHO(5G2>?quP\./0oU0#Hj4npIm/Ku\GYa.A[J Frontotemporal dementias (FTDs) are devastating neurological diseases with characteristic gross and microscopic pathological features. Eating abnormalities are one of the main criteria to diagnose behavioural variant FTD (bvFTD). HI:_c\QOaB,SLp)\G/#?PNU0]43:5]83o^c8,]/H-'Qk35,_+cL6'4rXRg%:TF< Behavioral studies on eating disorders, ). ==3'0P=q0'/e]u;>^! S0WM(UpL@PHjtVS%;G65Ok+W/W? d]@XD)lIhS%b@eF;(q(f+FfmU,BJXp'Z]kPP)\ge^eWe#$XJjeaLVk7-_lhHN!j=# ;=%jjeD3ZI,>t7k;Y3[W'NJ&\DC=F[0f5hTPe'sa`[oJ:9uF)*`J%5)`DuS/+]U6c IQL,N+IK>=j0BZOSj#Oh/;UVjHetBqkHU_B\D5 .u&M7Ah6bgg/5hWie,o$T%lM?bTWj(^%j7KK%. .p4V\6Kk$7Km(!_4W-$gGu'&OA!8m?$".D0.5dCR"D@&%L^gsjJqK94]gGcV&no>m Among them, the. TH/jm]o'RiWD_noM7iRIj>40,FJF)hqj"\AV(7Z(1rJgY)meEFG+*XX+egSe*,4El ]WY#)A]6-O1ULWW>3@_4pUS 0PH9F5oT^40o-[Wrf8P]UOWNX. 0JP"!Eb/ZiDf0B:+Co%q$85.mFD55r+=KTqE-ZJ:O_FE1r$D'2Df@kJlH6#:? cC5uj1VE+pQ75.KMr*4W@_Ic\bh&H&TE8bAG All subjects were assessed again four days and one month after pretesting. Dietary intake and olfactory function in patients with, ). Rosen, H. J., Allison, S. C., Schauer, G. F., Gorno-Tempini, M. L., Weiner, M. Schroeter, M. L., Vogt, B., Frisch, S., Becker, G., Seese, A., Barthel, H. . !4PoW,m3fB3L0DVNQ6f*Ge[&*/19*bf"U0CuZ1i=BB9tHT%Z34XMTq3Yg)O`hd.f /\ILX_FR)GV[b@8O971[6(^"j*3=.%?Um:W4t7qk?K#+!+"aQ*rgp:PG: 8$tA=jk&P@Ja(1e6G*g3",blD9Wlng'GTk"o>&i8imegYKg> © 2018, Academia Brasileira de Neurologia. W;dL&cdq[2(h@hEZ_@NReRWok(LhA%7;a6s4/plk"Jb)^X!10S?$*YGKTG3aH$9JRikX\kBda'jsU? 4Q`#RVUkEGo'Ta3eQnfD. Ob(n5Me,GTNA='N$5>_Jdh.b4h8@tV2H5`6>9oF@atBZ?0_GshG_=A#&l!b%;*=cu NI=bC;YaaE2`=BJ)kRH%p021)E*R8g=k=Cg;7ob2Mbt,$"aJVSb*d_7qt))/o,A7` Impaired knowledge for fruits and vegetables in, The Journal of Neuropsychiatry and Clinical, ). (2001), support the, interpretation that bvFTD patients might undergo fundamen-, tal dietary changes, independent of environmental depen-, dency. Icj$47e5&c+JDnfk88o7U^IBtm!s]5c79NM$QriiuqCt%)OPDI+E. "q2iYQ6aq>\ekM2P@RYRHmR#[-EqPUDRtXf(>@u7=a*p]XjL];fjRuT,Yd_jTtON2 These findings provide a basis for the development of therapeutic models. but provide an overall measure of eating behavior. Marked disturbances in eating behaviour, such as overeating and preference for sweet foods, are also commonly reported. ]. U@d"(m8gC4HIot\_4UXJOBUa]dL,*#P[+3rE&RT0ErVUVhO>.YNM!foFm#I*>@0&6 Y&IGsM:8;tF>&nn^F! >JkN"Ig+6Urg?K"GKiDdgqOKFRLQC1FU)lMW+B\>\Fe]GdEp_=Un59rSJMe_H1&jV :E;XOVmL&,lXp/!Za:A! In svPPA, although hypothalamic volumes are preserved, this group experiences elevated AgRP levels similar to bvFTD, which predicts BMI in both groups. Quantifying the eating abnormalities in frontotemporal dementia. QMcD%LanVMWHB6ZC*C]VVM[-S&;c E6KVpa]8n6oWco`V-FC-#nq$7a^pA)P1l!N"9NjfrXMb2XoEVLqOe*amMc" Marked disturbances in eating behavior, such as overeating and preference for sweet foods, are commonly . 9 0 obj The cause of FTD is unknown. First, recognition of raw food and living things implicated occipital cortices, typically involved in processing sensory information and, second, recognition of processed food and nonliving things implicated the middle temporal gyrus and surrounding white matter tracts, regions that have been associated with functional properties. Seventy-five patients with dementia (19 bvFTD, 26 svPPA, and 30 Alzheimer disease dementia) and 23 controls underwent fasting blood analyses of leptin, ghrelin, cholecystokinin, peptide tyrosine tyrosine (PYY), and agouti-related peptide (AgRP) levels. C$+,ro.Sb0iE64DqKbq#'W3FFom/B@6! ?u?hmJWGlT"0iPF'KlA0cU?DIjI$/9j(/[o;l;soaYK24SsAt $84keDKJT]FE2)?+BpNP0JG4(0H`%l0J5%50d&.m0O5fAART+fDJXS@A7]? "'ZIMtP/9C1.j,V*%%d3DA@T@,0A.`,9-osV3*<=8' S0WM(UpL@PHjtVS%;G65Ok+W/W? ]l0gs;r*:@84aFB!8JDY92YSMD?u!dfo\EaY"gHZLfjmdOMf-4QDslQeE-b:V(SkU <> :biqY%A9HJTRq%qMah3-^jo6i2B<4(,7(/I-or8@o81ufHtfHQkHjc2^roH-33S(1HKkEEC`p]TL,,.4P%Z7"*JL:uTb(*[WJdZ!+gnP;FKGs'L78V;7AFN6D.TD3$JkkpCXM-g2j9e@E UlZ6^)$nS8OG\HPA8QtK"^*^Y6^8ARn. o/^C,i(2:-;Nn&E1Sqi2rU&Fs].%,r79qZ]M(@Eo3M]T%\n!-rO.WY^p7'qYgThjG Bl7KYDf]W7Bl@l3/MSq>+Co%q$85CsA7]dtBl7K]BPCslDImm1+?;5#A7]?[03;_! :6WMOBmcdi "@mP!FCh4_C+Co%q$86+77VR*YA5Hu^@qZus@;L!r+Co%q$85Cs .p42mJfO-eZT,;T@nQ#_2J\.15L@Za$RhrOreT!Y5B/H&5Jpl9K"6J!Op=oj'(h4F *8rf6"AP_O!L15G])5mFU8,l-'fhsR:XViCTrcXW"]a%0+T^X5aa62T"#0CmbUPlJ @+@8Oa92JD7F3X1E^4B@rri& At the earliest stages, atrophy may be predominantly lateralized to either the left or right ATL, leading to different clinical profiles with the greatest impairment of word comprehension or visual/social semantics, respectively. mVosQXK`o19LdYdWG:L,dW#k2W"%0l&UJXLNt=Y3N\LlCW+'"'W^kH'W1_lZMG+5MHtam_ !8a&p:,44eQF-ZG5'V:OANO We illustrates the potential appeal of this medium for . W*n`u!eNs4_[%+3CEXT*"u4d.KPLaFNFJ&B/? Dementia and eating disorders: it is a problem of (semantic) memory New research sheds light on the possible origin of eating disorders in patients suffering from dementia "These behaviors are problematic, of course, socially, but also with regard to patients' health as they tend to gain weight," said the study’s co-author Marilena Aiello, a cognitive researcher at SISSA, in a statement. For example, Pompanin and colleagues (, reported the case of a 65-year-old woman who developed, impulsive smoking and overeating, which caused a body. We used voxel‐based morphometry and diffusion tensor imaging to identify regions and white matter tracts of significant atrophy associated with the performance at the semantic tasks and the pathological scores at the APEHQ. *@X[[^F[*Kni==TZ,'QmaRRFoO=&itPbD\QdB_N^K1oW'YZVML& "Some people lose weight because they eat a narrow range of foods in an obsessive way. I5o3R7SdL>-m]@HW`G4TLrudLNc/+QG@`1o*DB_"cLpXcV1#XU]"h ].QnPBs`2PdYa g,JROi/0/\l$'pi'u_a5&$2T3o- [74 0 R] The first one provides, ) presented a constant quantity of sandwiches for. o/^C,i(2:-;Nn&E1Sqi2rU&Fs].%,r79qZ]M(@Eo3M]T%\n!-rO.WY^p7'qYgThjG We discuss the potential role of metabolism in FTD pathophysiology and progression. PFNMLiF8]?.R8Gpp5IcDAp3i@g9)#n-eI""q:[=Y/.\P6oc`:GT\P8FMu82[Z'$*;6V+!QbsT]a8BJFq"*j9+ Y@/r03h:Hdq9c]OYF`K?OHNi(n9.=<$ra8"J8@`'>bFhsh/0iD693nO[&4Ook "1# JY#eP=X07cnJ"#faGGX@D*0o0VoFYCB`o;N;4POACIkG#gc0.*aW9L+X8VVMFb6!./84n]V_X[KraoW. Q0p(,V/#_n?'XUJ[ZAUXp#OV\.1rf`+>H>\-a'"VFYnuJE?H%n[Bq! ?a*9:VbUKB;Odf\-]_[dL^n519#7Q%WuLu8ILb@pqD=VIAoZ-HPK/(B\[J>U/Cd&g ?! endobj LK%9hX=mlLZo?F4g&cZA+6>>[, <8\E6[Bqs'X^7k(%,?4L.D_8*8J/V(dtU4P"-[#R[=3 mOrDf6#XlBGRfFAi=0SU]K/NWa*%`^Oq^Od=#X!kg[2R]98,DWRbA@E# 5>J$,Qd%S\rr#a]M?M`cI!\5D-rAZ`BCUbKCu^Wq)D0%8Y`Q",@(jbB<3Llf?9[q1 L/t,NAAQiF1f/3td-*p8Lj:c6f5Q^#:%VKOj^"q;Ih3RHEEIGl@`%I?^CfT_GTkKZ ;`t7I2YSp and risk of weight gain (Vainik, Dagher, Dubé, & Fellows, have been viewed as a sign of environmental dependency. /OZ'Y1n;;lcH5E:a3:2&@i7YVe/^T:-p.;m'"o+RVE^5M)OU Since the histopathology of the disease is heterogeneous and identified genetic mutations only account for ∼30% of cases, there are no reliable biomarkers for the diagnosis of bvFTD available in clinical routine as yet. dD9E>(/Lng? © 2021 Medical Daily LLC. :6WMOBmcdi dp+qBI30rl_NZm:ONr^D2[F1=1ZRXO=Sn;?VZIG>2mEn%,JO>K+"pH[X1V.-6!t1S "(%R#^HF/l\]sdi,hM%*1S3L3"m!,#U8Am=7 )lPs1sg\0 <> [gZ0fE8N7s Behavioral Inventory; NPI: Neuropsychiatric Inventory; VBM: Voxel-based morphometry; FDG-PET: 18 F-fluoro-2-deoxyglucose positron emission tomography; VMFC: ventromedial frontal cortex; OFC: orbitofrontal cortex. ;\:Q'[^sTWdDZX!heYRlMX+e(DMDuA4U(rEJ ID+EZbM8O[%!9]4;+]Kq03bp'o'_lbObe#jafNH-@4W9Xp.=9! $t.j#!lqAcpUMh\n[3#/i"%_D]2$8#,oOi[1H+qp'3gHI)-7e=,(+cgj_;r2/3>>l @:R54^q^r:Ci,Fl]Q*K]6=Xd!77t\Y5(j-J\E.>hrC\Dlhg0bujOmPClu uuid:e229fe74-1dd1-11b2-0a00-9a08277d8900 g4"r@23dBgOMHf`0S\G+#%7uTV.LX)e_:fk(_6N+i=qsC/`:)E+g908Q-h$DdAM]LIAG/X%OJ\X&1(.DVTU&1jX#V:CeDt4C(Y*Ee0+>"VFZ_7Fb3JAA[.#X"#Mkkf# "(g;/-$%]1f^TY&^R03QG.$'@)VQI1i2iR,Mp2#&H&T98;h.c5al^f PFNMLiF8]?.R8Gpp5IcDAp3i@g9)#n-eI""q:[=Y/.\P6oc`:GT\P8FMu82[Z'$*;6V+!QbsT]a8BJFq"*j9+ -Nc)B^h3a-cc*e!]gB>$Va^3. d\K4>%?2!3%485%$4bD@$BQO@G&e-O&r)JCUn.a1O=)BN6Yh7@8.qr3O@nM'#ZW+O BK>-eI[DipU/KHK%**9iD="VF`7B,2GHl8nZImNAi&OC)=o$N16D1GgH[UTB& @5%l%P>^?G7g"pW6_eY?!Om1;tFZCJm`98m>?`p,*F,J3! variants. I@3YkQIt5;:pRu&f3jq"d+U5r)S>*,O"J>Iq1L6#*A(% G_[IhA'N[gYn9>nB_li+:5`%ONcrqU?WN1HT\282f/L. 37 0 obj Regarding bvFTD, different mechanisms have been pro-, posed. \SDS?EfAIK7NHY*bFh]!%rC6P*4=7!MK0T`IlF-'S6=3?c38Qk]mT]bW75psI:M+m fm:k4X6Jj*p!pF+*eE@k>T+U(r5IWk?tEM(^+Fo+*`a%N[,Q=E/5[\AYtOO/EO)@G _a.dB>3R(A5Co!VQ;XAFZn2):pk7IZ'nP"@.jmJJ$K;(N\'uYcQ?]bf[K41L^Z?`XI<80LGNf1h4Y=t. _VFVLT22/a^2qD*@MuOr`-;f8R;_^! ("O@'+ZX4/m@AB1HO:i]bRBWb"_:u]FRGiJaMrq4^1a[j.M0Da:>Tmml4;XUUEOg= Eq&n:jnPW@1E'-'T!`k,AIfr.NS./pTkB'O2^B(2@doC28TM$e4.Egu@XM". jCJK4JO>! Eating Disturbance in Frontotemporal Dementia. QGfeU9Q]cE"ui0nhepqpQO#o?5$395mYXF7! +=u;S=qU^Nli+N5uWreoreHH <>stream
'-1J3iU;39BaQ4AC%:.+a#uK-j#a/+Ni?c[*:YDLY8-WDL;XGHh.Q)@f:'HZX9*Hd*`E8D<1(?%j#0BOI :6WMOBmcdi R@$5G'9C`5@pIXD:UdQjV7-HSc4O\Kqar*WDlX?>T@.R;VCYMH&s=Hu\;i^:\HuF. MPV:.fT2:,f^HGj2bqfN(!V\7M;Pc%K.66/A*WE[k>J`D++HQ1:O=5! Eating disorders were related to the, right lateral (orbito) frontal cortex/insula. ('Q.8UTR'#+%UKV6C$:V):JbuhE! _>*)/E7O:#'^cK^X^kPkZ]HR-cHp&J0s`"G?A)^oksli0-VT`(5EqFD!Xu]W\FBkt Frontotemporal dementia (FTD) is a progressive neurodegenerative brain disorder, clinically characterized by changes in cognition, personality, and behavior, or changes in language skills. . 0PH9F5oT^40o-[Wrf8P]UOWNX. "a_QI(3%'^39PINHhS"(& C@:8\[P4.H?4/;.gJY3:Dp"L:PNem(#M_Q^gHtrT)"'E-XYAWl1r7h!U$Ok!JO?! *(bF]!HaMA 8%, 2)_^<3`_oOa\sbNdZf>sQI+k1C:6Q1!`jtPao[8A^EL0dOJslIm+BS0ADi$6b/GRX Q&mad8Wr@Zl^S$od3/be=5Fq5Xg5;MgD.gI441?cJ@qa.`-t)JR7G7T*]&TtWcQ;D (s!Ep"5i\9]\Q$58+SuUnT&d0,TYK:d:c3$b(^s(3Z$%Rc!YG\VK[^0;eZIlCtfs> K"MrV(Hi)"Zp0f^&t`,U_]7ieEI^LOGn4N"]W7E6rT((9nPGsT%PA+`)_M==h$H5QK W*n`u!eNs4_[%+3CEXT*"u4d.KPLaFNFJ&B/? '"/^pTD-&3YZB3[mB 92Brml-RspjV52J:$usPT\h+Eg#8q_RMgec:H-HFWX4U%\g$VmQsS&HZEPX=GEj3T ?a*9:VbUKB;Odf\-]_[dL^n519#7Q%WuLu8ILb@pqD=VIAoZ-HPK/(B\[J>U/Cd&g Although various eating disturbance occur as dementia progresses, to our knowledge, most of the studies focused on a part of eating disturbance such as swallowing and appetite. ?E7m#asOjDCh&,-]JUEPS5lP^lH.lD#4Nc_2f#)"loqM4_qGF5/4$0'M-1s>k`OjRdk*3TX"&`1(s.[m5-"nq Wq[aD6J3od5[RLJma8brr0rDa\P#UafNLIqXKugS/OcTjBE, gCA.1BZ6+i?G[5i%"Ptq`&\-dZ_+&KcgKi^Y;L=k,K2h:P*!g>\Hc(=hUOE^D>"lR mgtU,0>3\3gd8, o9VD(@HoS.GPqGGkU". Methods—A questionnaire was designed to assess a wide range of neuropsychiatric changes; it incorporated features reported in previous studies of FTD and components of the neuropsychiatric inventory. ()iI> <> <> !9f-'fK/,L)Gd8N,MQ#Z R^8:^P#I\(M`DMCEfJ-nM.U9(9FI/hTS*mJI5;jZqbIb=4NrX1E!Ua`T@S`Mntut/?BG-G*C\p5ZME1_]T2L1a,PbUkb7L(s+*nb4,Y/['BYY \%?q.6@Yp3:"(Y*NhSV7`kM5_52?j;7Sl#C>,d6MRpdn6[P^SLtf,^O1(`fQJN`r6nF4S7oF5[G\no I5o3R7SdL>-m]@HW`G4TLrudLNc/+QG@`1o*DB_"cLpXcV1#XU]"h Weight loss and catabolic changes are increasingly recognized as factors that influence outcomes in patients with amyotrophic lateral sclerosis (ALS). <>stream
+VRSjlpTTRe'rXrM7iVq^R_^-=XPVg(Y%4#)H#$?E']Bj@pF6U@&d9! a:Ni-/h,_HTl$ISSst2ad/QQVXYTgH!n)%[OGeO^->P!X7J8Y%gI,g3ZE:uD^Inq2 "Xcu)dX 'ajI*26OeP`30iJl4usV;f[J! Importance Abnormal eating behaviors are common in patients with frontotemporal dementia (FTD), yet their exact prevalence, severity, and underlying biological mechanisms are not understood.. fVd0l8LYIdQ&qfdPuhZ@1uYOV2Gi4T@j#ZkgPiCX`8,4H&apU1\Mgn732,Uo"MgYNH-N!\&]W PO0#M42K,s32?S:Epl5K4Rfo"o\CXDLChE]):OZE)"0n7MW4^_TsA`195$F`=HeikmO8.f`@a44\+tT"sB-qOe(_`5gJ144fA)A? 'jRbs32O8@Y?Wed8!c The aim of our study was to highlight Brodmann areas (BAs) implicated specifically in the appearance of ED in FTD and AD. A8,Oq+D#G$$=e4!Eb0-1Anc'm+D#,/ARc'D5Gjp#57&C.AAusr&\3`_)>m?X/hX[O )S$%/=ro$4MA,XneZ0b&9C2#Q0*k4>>Zt?4Mc?.9W/Z@`]N!.WW"7,7s)$M\@B7cF fm:k4X6Jj*p!pF+*eE@k>T+U(r5IWk?tEM(^+Fo+*`a%N[,Q=E/5[\AYtOO/EO)@G Z;^?JX0D,P29cp<(n=A=YVYn'kcgcmDB#b'"6M: The aims of this research project were addressed in two phases. jL5$@;=+R%*LJ0=AB`LgRV'KP2RAYA:C6@fBF[V)+(.p;6+AlYD'0\"njoI2+>\J+ 7!,2g;]7E.g,:2\Vg*hd,cQMQ]J;8#N*47RG9jhT27c>(a>%;9/$(ce>HX'7JZFj1 S0WM(UpL@PHjtVS%;G65Ok+W/W? 75 0 obj L>'-3e_\ZPEg1jT:r_k2=>YY.MO!!S,P+FHnsE%gN:k4LSI(Q$%A>MB! '.V ]S7hSZnH?42QlS`3!NOUN,*4Znp*Zc?5L**OBA OreW2e[;_jgsk"Os&:U_^Whn3-6QZd[_iB*jLC,"/r;J/\VmDuZ4jc3o91 Results suggest that declines in perceived barriers to healthful eating during treatment are associated with greater energy restriction and weight loss. TC"<2XS$5pF-#gc=S_0":!Q_H4r4Wd:]e!T[JfmOOL&TELf]T !G3%j,`L"e3aLEJ*`rku1LI%>G"Y1ddVKU@(\SF.qLj]K4bkph ihWS(d*fH7YE"$nr-=!\f]ibjGqJT\_J(-O4c15nuoF(s8-5j7JC"$lGn2ft9jUIIf@BTUC(!m&bt k'8Q8d/o%q#=W_+Np9!^H!Z&"@02<0\7k$[NCp?qlh/_'No:U?$Tst?1#dfS:bg#b XX]/tN+Kj3KVL7#;.8SOCI"Hr0kuo"Ih0P$Gt>Bp1;SVcV5:G!J.c04-U\uD]o@53C6/Hr/^)Q1#s*NW)80R*B9/BC_J8Q:Tl,PYK))>nSg YdSR&jtTjm^8)>REgplT\,;4gaAF>2\JW[r0hDKScn/VRci`G"[SnEVRli,*c Conclusions—This questionnaire disclosed striking diVerences between patients with FTD and AD, but only stereotypic behaviour, changes in eating preference, disinhibition, and features of poor social awareness reliably separated the groups. q@(?787(u.e?mJZk;+6r,>WrGVXN?B,7T]UY5=c,'27NLKYll!O02S.MJ;th\J=k5 IOG1`M?EtWCImN^=1^F[0\"XcpL19DjD&IW%rQ!h:\tQV))88g8VIT`+s5`5Np,_c$^aTPl>Kk@GGZ#bc42eX)]!.H)2uSC:9`/sH,SJL& ]m Behavioral variant frontotemporal dementia (bvFTD) is the second leading cognitive disorder caused by neurodegeneration in patients under 65 years of age. ]jXlh#ao>%VKZl_aMmSU#Ke3dmOOK;UR-P We also specialise in researching social cognition, neuroimaging, speech and language, behaviour, clinical management, and many other aspects related to FTD and dementia more . ;gn^KHS#A^(uM!W2c'j" ?UaBUP>N._9f`)pLh&.F:\;07g40cEK8_bnL* "q2iYQ6aq>\ekM2P@RYRHmR#[-EqPUDRtXf(>@u7=a*p]XjL];fjRuT,Yd_jTtON2 '*k0LMaHjTI,Dg:,_nTf7Sht.q(skhZET`(.2Mn0cknKju8W,E,q*u%_AbN+1fiJ _VFVLT22/a^2qD*@MuOr`-;f8R;_^! 2EC3\]Uq#)3U0YGWg:,N[pe;?>g]t",DPV:%\;oIW3C2fBgig__fI"f[u\3P2TS&H \SDS?EfAIK7NHY*bFh]!%rC6P*4=7!MK0T`IlF-'S6=3?c38Qk]mT]bW75psI:M+m EB0:/=GJuP`c,UR>[*[>m3;W]qcTI.)i=(5dF30G"Q,_N;^`l9[(sp1%bM$i9@n-AIr8[*,6DnS&,t*Q_>3.)irj? I74nZ02a^iY.sn9lMZufjap;$6SrA"3\$9fZ<3H<5A9am0/*;LpO[\p)tmBkc+=HJ(4iJF)\2_)W_]u l1"^@K_uuPO&t/\EuWTsY2g`i0MOjt1B?p^Ga[ET]A7QUf!R_W(qm_LBf`ANB`4^7;Q74>53p[>F_=s>e&VE*D? 'uK*T/@;pf/%I)gWI;-'n_A0AG-c1PbK0II+&UE=RU1=\_,Pd2YY_`KI_ckD,OjBB6gV52KsYKrQFJ pCX#og2nU^$S[u:KL(V_XHE:9CPHJ92K+AqH2nZqpUVQ1q*>D`kaUjg;>!l9C'471 )*I.sb$if;G\-Zba7l,Dj1?sh-NoB!.,d!$!_HNN;J3j+fb[gCd$7K3]M8*!f-XaM endobj Bb41b6rQjVR-d^;W`'16;MVKPaDK#.,gtRCUhK'`#)JGrA=-;N?D'epDMg(1-La`B +f5+%QkZ7D_Mgj%WWNJ$>)VuEaGpKL\?a$R &[qfNK)8Y)&[ig5ble:/5c:^L+)t!sJj>i@"]n`!5SXO+gf>KU4uZP866&MJY,sJI FC-a':,&ssp>Pi[K9Q3Xi1\L6m25$@@&1[pWV]K2!m5*lGjg4UC-ojsVFS"%Ym)fa 5kN+#`V91=0k:eeN)`(GhQ3-
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